Noise-induced metastability in biochemical networks.

نویسندگان

  • Tommaso Biancalani
  • Tim Rogers
  • Alan J McKane
چکیده

Intracellular biochemical reactions exhibit a rich dynamical phenomenology which cannot be explained within the framework of mean-field rate equations and additive noise. Here, we show that the presence of metastable states and radically different time scales are general features of a broad class of autocatalytic reaction networks, and that this fact may be exploited to gain analytical results. The latter point is demonstrated by a treatment of the paradigmatic Togashi-Kaneko reaction, which has resisted theoretical analysis for the last decade.

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عنوان ژورنال:
  • Physical review. E, Statistical, nonlinear, and soft matter physics

دوره 86 1 Pt 1  شماره 

صفحات  -

تاریخ انتشار 2012